English

Zoekresultaten

Zoekopdracht: subjects: "Health and Nutrition"

TitelCost-effectiveness of algorithms for confirmation test of human African trypanosomiasis  
AuteursP. Lutumba, F. Meheus, J. Robays, C. Miaka, V. Kande, P. Büscher, B. Dujardin, M. Boelaert
Jaar2007
TijdschriftEmerging Infectious Diseases
Jaargang13
Serienummer10
Pagina's1484-1490
OrganisatieKIT - Royal Tropical Institute
OnderwerpHealth and Nutrition
Trefwoordendisease prevention and control, health
Regio'sEastern Africa, Southern Africa, Western Africa, Africa
SamenvattingThe control of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) is compromised by low sensitivity of the routinely used parasitologic confirmation tests. More sensitive alternatives, such as mini-anion exchange centrifugation technique (mAECT) or capillary tube centrifugation (CTC), are more expensive. We used formal decision analysis to assess the cost-effectiveness of alternative HAT confirmation algorithms in terms of cost per life saved. The effectiveness of the standard method, a combination of lymph node puncture (LNP), fresh blood examination (FBE), and thick blood film (TBF), was 36.8%; the LNP-FBE-CTC-mAECT sequence reached almost 80%. The cost per person examined ranged from €1.56 for LNPFBE-TBF to €2.99 for LNP-TBF-CTC-mAECT-CATT (cardagglutination test for trypanosomiasis) titration. LNP-TBFCTC-mAECT was the most cost effective in terms of cost per life saved. HAT confirmation algorithms that incorporate concentration techniques are more effective and efficient than the algorithms that are currently and routinely used by several T.b. gambiense control programs.  
TaalEngels
CategorieResearch
Soort documentArtikel
RechtenCopyright status unknown
Download bestand